Evaluating reliable and clinically significant changes in health outcomes of a mindfulness-based cognitive defusion training program among older adults with mild cognitive impairment: a randomized controlled trial.
Age and ageing March 28, 2025 Yinxia Ren, Bei Wu, Chenxi Ge et al. 3 citations
An 8-week mindfulness-based contextual cognitive defusion training program, followed by 12 weeks of unsupervised practice, reduced perceived stress and improved memory, psychomotor speed, and mindfulness awareness in community-dwelling older adults with mild cognitive impairment. In a randomized trial with 102 participants, those in the program showed significantly greater stress reduction than a health promotion control group at both 8 and 20 weeks. At the individual level, 59% of intervention participants showed reliable improvement in perceived stress at 8 weeks, rising to 75% at 20 weeks, with 39% achieving clinically significant change. No improvement in global cognitive function was seen at the individual level.