School of Medicine, Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, Huzhou University, Huzhou, Zhejiang 313000, China.
2 papers in the library · 16 citations · publishing 2020-2025
Adding ketamine to propofol-electroconvulsive therapy (ECT) improves outcomes for patients with depression resistant to ECT alone. In 28 patients, six alternating sessions of ketamine and propofol-ECT over two weeks increased global functional connectivity density in the left temporal and subgenual anterior cingulate cortex and decreased functional connectivity strength within the default mode network. Although the functional brain changes lasted 10 days, the clinical benefit—measured by the Hamilton Depression Scale—lasted only 7 days, indicating a disconnect between brain alterations and symptom relief. The combination offers a short-term improvement, but its effect is limited to one week.
An 8-week mindfulness-based contextual cognitive defusion training program, followed by 12 weeks of unsupervised practice, reduced perceived stress and improved memory, psychomotor speed, and mindfulness awareness in community-dwelling older adults with mild cognitive impairment. In a randomized trial with 102 participants, those in the program showed significantly greater stress reduction than a health promotion control group at both 8 and 20 weeks. At the individual level, 59% of intervention participants showed reliable improvement in perceived stress at 8 weeks, rising to 75% at 20 weeks, with 39% achieving clinically significant change. No improvement in global cognitive function was seen at the individual level.