Application of microarray patches for the transdermal administration of psychedelic drugs in micro-doses.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V February 1, 2025 Octavio E Fandiño, Aaron R J Hutton, Chunyang Zhang et al. 4 citations
Hydrogel-forming microarray patches (HF-MAPs) can deliver small doses of the psychedelic compounds N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), and mescaline (MES) through the skin. In tests using excised neonatal porcine skin, a reservoir containing polyethylene glycol 400 enabled permeation of 60.71% for DMT, 59.61% for 5-MeO-DMT, and 41.85% for MES. Pharmacokinetic studies in rats showed that DMT delivered via HF-MAP had a significantly greater area under the curve (7186 ± 1296 ng/mL*h) compared to intramuscular injection (1803 ± 53.25 ng/mL*h), with a relative bioavailability of about 72%. This suggests HF-MAP technology could reduce dosing frequency for DMT microdosing.