Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders.
Journal of addiction psychiatry January 1, 2024 Gianni Martire, Daniel Sipple, David Baron et al. 341 citations
Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) share overlapping neurobiological mechanisms, particularly reward deficiency and stress-like anti-reward processes. The authors propose reclassifying BPD as a "traumatic personality stress disorder" (TPSD) to unify therapeutic strategies that may stabilize dopaminergic reward function, such as psychedelic-assisted therapy (PAT). They argue that PAT could treat trauma-induced personality disorders by addressing these shared mechanisms. Reframing BPD as TPSD may lead to more effective, personalized interventions, reduce stigma, and improve understanding of underlying mechanisms, benefiting conditions characterized by anhedonia, negative affect, hypervigilance, and dissociation.