European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
May 1, 2024
Víctor De la Peña-arteaga, Marta Cano, Daniel Porta-Casteràs et al.
5 citations
In patients with obsessive-compulsive disorder (OCD) undergoing a 3-month mindfulness-based cognitive therapy (MBCT) programme, distinct baseline brain connectivity patterns were associated with four clinical domains: positive affect, negative affect, anxiety sensitivity, and rumination. Key brain nodes—the precuneus and frontopolar cortex—within the ventral default mode network and frontostriatal network showed predictive and response associations with clinical changes. MBCT may modulate connectivity in these networks, potentially reducing symptoms across domains. These network-based biomarkers could help personalize treatment and identify patients most likely to benefit from MBCT.
Revista de psiquiatria y salud mental
January 1, 2023
Neus Miquel-Giner, Muriel Vicent-Gil, Ignacio Martínez-zalacaín et al.
4 citations
About 40-50% of patients with obsessive-compulsive disorder (OCD) continue to experience obsessions and compulsions after first-line treatments. Mindfulness-based cognitive therapy (MBCT) is proposed as an augmentation strategy to help patients decentre from distressful thoughts, potentially increasing non-reactivity and reducing compulsions. This randomized clinical trial of 60 OCD patients who did not respond to first-line treatments will compare an MBCT program (10 weekly 120-minute sessions) with treatment as usual. The primary outcome is change in OCD severity, measured by clinician and self-reported assessments. Comprehensive evaluations will include comorbid clinical variables, neuropsychological functioning, thought content, and structural and functional neuroimaging at baseline and post-intervention. This is the first RCT in this population to examine clinical, neuropsychological, and neuroimaging variables together to identify neural patterns associated with MBCT response.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
April 17, 2025
Marcial Arredondo, Ferran Mestanza, Ruth Carpio et al.
1 citation
An 8-week mindfulness and compassion program for cancer patients and their relatives, delivered in person and online, was feasible within a public hospital setting. Among 142 evaluable participants, 90 completed the program. Scores on measures of general psychological distress and anxiety and depression significantly decreased after the program. In qualitative feedback, participants reported greater awareness in health decisions, improved relationship with their illness, emotional support, and enhanced daily life. The program led to significant improvements in psychological well-being for both patients and their relatives.