Psychedelic Research for Alcohol Use Disorder with Comorbid Major Depressive Disorder: An Unmet Need.
Current psychiatry reports December 1, 2024 Daan de Jonge, Pim B van der Meer, Cornelis Kramers et al. 2 citations
A narrative review of psilocybin- and LSD-assisted treatment for alcohol use disorder (AUD) and major depressive disorder (MDD) finds growing evidence that psilocybin produces a sustained reduction in drinking frequency among people with AUD, and a recent meta-analysis shows psilocybin therapy yields a large and consistent decrease in depressive symptoms compared to no treatment. AUD and MDD frequently co-occur, and this comorbidity worsens symptoms of both disorders and complicates treatment. The authors argue that an integrated therapy addressing both conditions simultaneously could benefit such patients and call for more research on psilocybin in this dual-diagnosis population.