Scientific reports
February 8, 2024
Rosalind G McAlpine, George Blackburne, Sunjeev K Kamboj
24 citations
A new 20-item Psychedelic Preparedness Scale (PPS) was developed and validated to measure how well participants are prepared for psychedelic experiences. Using an iterative Delphi-focus group method and input from clinicians, researchers, and psychedelic users, the scale identifies four factors: Knowledge-Expectations, Intention-Preparation, Psychophysical-Readiness, and Support-Planning. In two large online samples (N = 516 and N = 716) and a psilocybin retreat group (N = 46), the PPS showed excellent reliability and evidence for convergent, divergent, and discriminant validity. People scoring higher on preparedness before a psychedelic experience had better mental health and wellbeing outcomes afterward, indicating the scale can predict who may benefit or be less likely to experience harm.
Scientific reports
February 19, 2024
Rosalind G McAlpine, Matthew D Sacchet, Otto Simonsson et al.
13 citations
A 21-day self-directed digital course (DIPP) was co-designed to improve psychedelic preparation. The intervention, built on a four-factor model of psychedelic preparedness, was developed through two mixed-methods studies: interviews with 19 past high-dose psilocybin retreat attendees and co-design workshops with 28 current retreat participants. The course includes daily meditation, weekly module exercises, and mood tracking. The authors suggest DIPP offers a scalable, comprehensive tool to enhance safety and therapeutic benefits by addressing knowledge, psychophysical readiness, safety planning, and intention.
Cell reports
July 22, 2025
George Blackburne, Rosalind G McAlpine, Marco Fabus et al.
10 citations
Inhaling a high dose of vaporized synthetic 5-MeO-DMT radically reorganizes low-frequency brain oscillations, making them heterogeneous, viscous, and nonrecurring, and halting their typical forward and backward travel across the cortex. This reorganization also causes broadband neural activity to become more stable and low-dimensional, with increased energy barriers for rapid global shifts. These findings, based on EEG data from 29 healthy individuals, provide a detailed account of how the drug sculpts human brain dynamics and reveal atypical cortical slow-wave behaviors relevant to neuroscientific models of serotonergic psychedelics.
Journal of psychopharmacology (Oxford, England)
May 23, 2026
Joanna Kuc, Rosalind G McAlpine, Amelia Sellers et al.
A short-acting psychedelic, 5-MeO-DMT, shifts speech from external focus to introspection. In 29 participants who kept daily voice journals two weeks before and after a single 12 mg dose, language analysis showed increased cognitive words and fewer social words, while vocal quality changed with more jitter and shimmer. Baseline speech patterns predicted how prepared people felt, the intensity of emotional breakthrough, and later well-being. This is the first longitudinal study showing that vocal journaling can track and predict psychological transformation around a psychedelic retreat, offering a framework for monitoring preparation and integration periods.