Combined ibogaine and 5-MeO-DMT assisted therapy produced rapid and large improvements in mental health among trauma-exposed Special Operations Forces Veterans. In a sample of 86 male veterans, self-reported PTSD symptoms, depression, anxiety, insomnia severity, and post-concussive symptoms all significantly decreased from baseline to one-month follow-up. Satisfaction with life, psychological flexibility, and cognitive functioning also significantly improved. The therapeutic effects appeared durable up to six months. The study was a prospective clinical program evaluation conducted in Mexico, and the authors call for future controlled research to confirm these findings.
Psilocybin, the psychoactive compound in magic mushrooms, is linked to improved mental wellbeing on average, but few studies examine how effects differ by race. In a large online longitudinal study of 2,833 people planning naturalistic psilocybin use, race/ethnicity moderated changes in spiritual wellbeing, cognitive flexibility, and emotion regulation (expressive suppression) at 2–3 months post-experience, but not at 2–4 weeks. Participants of Color reported minor differences in context and subjective effects, such as being more likely to set an intention before use. Both groups showed comparable reductions in anxiety and depression, with no significant moderation by race.