Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.
BMC psychiatry October 14, 2024 Sisi Zheng, Francis Xiatian Zhang, Hubert P H Shum et al. 5 citations
Depersonalization-Derealization Disorder (DPD) disrupts self-consciousness and quality of life. Using fMRI, researchers identified distinct brain networks—Frontoparietal, Sensorimotor, and Default Mode—in 84 DPD patients and 67 healthy controls. Four dynamic functional network connectivity states emerged; State-1 differed significantly between groups. Negative correlations linked State-2 dwell time with clinical symptoms. Transcranial Direct Current Stimulation (tDCS) significantly changed State-2 dwell time in responders. The findings suggest brain dynamics may serve as a biomarker for diagnosis and personalized treatment.