Palliative care professionals see psilocybin-assisted therapy as a promising treatment for existential distress in patients with serious illnesses, but they have several concerns. In a qualitative study using World Café methodology with 16 palliative care professionals, participants identified needs for educational and certified training, medical legalization of psilocybin, more research, refined therapy protocols, and clarity on who dispenses the therapy, where it is given, and eligibility criteria. The acceptability of the therapy and expanding access appear interrelated, and developing guidelines will be essential for wider deployment.
A decision aid for psilocybin-assisted therapy (PAT) was developed to help patients and healthcare professionals weigh risks and benefits when considering treatment for existential distress in serious illness. The booklet, created with a multidisciplinary steering committee following international standards, covers PAT education, treatment comparisons, and personal reflection. Feedback from five patients and five healthcare professionals guided refinements to improve clarity, balance, and usability. The final version met acceptability and usability criteria, offering balanced information to support shared decision-making in palliative care.