Online mindfulness-based cognitive therapy for treatment-resistant depression: a parallel-arm randomized controlled feasibility trial.
Frontiers in psychology January 1, 2024 Michele Ferreira Rodrigues, Laiana Quagliato, Jose Carlos Appolinario et al. 5 citations
About 30% of people with major depressive disorder have treatment-resistant depression (TRD), which responds poorly to standard therapies. Online mindfulness-based cognitive therapy (eMBCT) delivered via live video sessions was tested in a small feasibility trial at a Brazilian institute. Twenty-eight outpatients with TRD were randomly assigned to either an 8-week eMBCT program or a control group. The eMBCT group showed large improvements in depression and anxiety symptoms, while the control group showed no significant changes. Between-group comparisons also favored eMBCT for reducing depression and improving clinical global impressions. eMBCT combined with medication appears feasible for TRD, though a future trial with a manualized control is needed.