Meta-correlation of the effect of ketamine and psilocybin induced subjective effects on therapeutic outcome.
Npj mental health research October 6, 2024 Jack D C Dahan, David Dadiomov, Tijmen Bostoen et al. 13 citations
Subjective effects of psychedelics like ketamine and psilocybin appear to play a modest role in their therapeutic outcomes for depression and substance use disorder. A meta-analysis of 23 ketamine studies (471 patients) and 8 psilocybin studies (183 patients) found that subjective experiences explained 5–10% of therapeutic improvement for ketamine and 24% for psilocybin. Psilocybin showed a greater mediating effect than ketamine, especially for depression. Substance use disorder treatment showed a larger mediating effect than depression, regardless of the drug.