Psilocybin increases optimistic engagement over time: computational modelling of behaviour in rats.
Translational psychiatry September 30, 2024 Elizabeth L Fisher, Ryan Smith, Kyna Conn et al. 14 citations
Psilocybin treatment in rats performing a reversal learning task led to more rewards through increased task engagement, driven by changes in forgetting rates and reduced loss aversion. Computational modeling suggests psilocybin may induce an optimism bias by altering how beliefs are updated, which could have implications for clinical conditions marked by pessimism.