Ralph Kupka

Amsterdam University Medical Center, Vrije Universiteit, Department of Psychiatry, Amsterdam, the Netherlands.

2 papers in the library · 19 citations · publishing 2021-2023

Papers

Adverse or therapeutic? A mixed-methods study investigating adverse effects of Mindfulness-Based Cognitive Therapy in bipolar disorder.

PLoS ONE December 2, 2021 Imke Hanssen, Vera Scheepbouwer, Marloes Huijbers et al. 12 citations

Adverse effects during Mindfulness-Based Cognitive Therapy for bipolar disorder are not rare but are generally not serious or long-lasting. In a randomized trial with 144 patients, 29 reported adverse effects, most frequently in the first three weeks. Seven types of adverse effects were observed: cognitive, perceptual, affective, somatic, conative, sense of self, and social. Higher baseline anxiety increased risk. More than half of patients later viewed the adverse effects as part of a therapeutic process rather than harmful. Influencing factors included predisposing, precipitating, perpetuating, and mitigating elements.

DOI: 10.1371/journal.pone.0259167 Full text

Mindfulness-based cognitive therapy v. treatment as usual in people with bipolar disorder: A multicentre, randomised controlled trial.

Psychological medicine October 1, 2023 Imke Hanssen, Marloes Huijbers, Eline Regeer et al. 7 citations

Adding mindfulness-based cognitive therapy (MBCT) to treatment as usual (TAU) for bipolar disorder did not reduce depressive symptoms more than TAU alone at post-treatment or at 15 months follow-up. The 144 participants with bipolar I or II were randomly assigned to MBCT plus TAU or TAU only. At post-treatment, MBCT improved mindfulness skills more than TAU. At follow-up, TAU was more effective than MBCT plus TAU for reducing trait anxiety and improving mindfulness skills and positive mental health. Participants with higher baseline depression and functional impairment benefited more from MBCT plus TAU, suggesting MBCT may help those with moderate to severe depression and impairment.

DOI: 10.1017/S0033291723000090 Full text Mindfulness-based cognitive therapy Bipolar disorder Effectiveness Randomised controlled trial