Adding mindfulness-based cognitive therapy (MBCT) to treatment as usual (TAU) for bipolar disorder did not reduce depressive symptoms more than TAU alone at post-treatment or at 15 months follow-up. The 144 participants with bipolar I or II were randomly assigned to MBCT plus TAU or TAU only. At post-treatment, MBCT improved mindfulness skills more than TAU. At follow-up, TAU was more effective than MBCT plus TAU for reducing trait anxiety and improving mindfulness skills and positive mental health. Participants with higher baseline depression and functional impairment benefited more from MBCT plus TAU, suggesting MBCT may help those with moderate to severe depression and impairment.
Mindfulness-Based Cognitive Therapy (MBCT) may reduce anxiety and depression in people with Parkinson's disease (PD), who are highly sensitive to stress. A randomized controlled trial will compare 8 weeks of MBCT to usual care in 124 PD patients with mild-to-moderate anxiety and depression, disease duration ≤10 years, and no prior mindfulness experience. Participants are followed for 12 months, with clinical, biochemical, and MRI assessments at baseline, 2 months, and 12 months. The primary outcome is change in Hospital Anxiety and Depression Scale score at 2 months. The trial also explores effects on motor symptoms, stress markers, and biomarkers of PD progression.