Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson's disease.
BMC neurology June 25, 2024 Anouk Van der Heide, Franziska Goltz, Nienke M De Vries et al. 5 citations
Mindfulness-Based Cognitive Therapy (MBCT) may reduce anxiety and depression in people with Parkinson's disease (PD), who are highly sensitive to stress. A randomized controlled trial will compare 8 weeks of MBCT to usual care in 124 PD patients with mild-to-moderate anxiety and depression, disease duration ≤10 years, and no prior mindfulness experience. Participants are followed for 12 months, with clinical, biochemical, and MRI assessments at baseline, 2 months, and 12 months. The primary outcome is change in Hospital Anxiety and Depression Scale score at 2 months. The trial also explores effects on motor symptoms, stress markers, and biomarkers of PD progression.