Neuropsychiatric Disease and Treatment
December 1, 2022
Peng Liu, Shanshan Zhang, Yun Liang et al.
16 citations
Adding esketamine to an antidepressant improves outcomes for people with treatment-resistant depression more than placebo plus antidepressant. Across seven randomized controlled trials involving 701 patients receiving esketamine plus antidepressant and 551 receiving placebo plus antidepressant, the combination led to greater reductions in depression severity scores (Montgomery-Asberg Depression Rating Scale and self-rating depression scale), higher response and remission rates at the end of the double-blind induction period, and better quality of life and health status ratings. Minor adverse reactions occurred with esketamine.
Frontiers in psychology
January 1, 2023
Yuehang Yang, Dawei Cao, Teng Lyu et al.
15 citations
A meta-analysis of 22 randomized controlled trials involving 2,216 patients found that mindfulness yoga exercise significantly reduces depressive symptoms, with a large combined effect size. The analysis included 1,101 patients in yoga intervention groups and 1,115 in control groups. Results showed substantial heterogeneity across studies, but the overall effect indicates yoga is effective for preventing and treating depression and improving mental health. Mindfulness yoga may serve as a non-medical, low-cost adjunct to pharmacological treatment for depression.
Actas espanolas de psiquiatria
April 1, 2024
Xiumei Li, Wei Gao, Jie Yu et al.
5 citations
In chronic kidney disease (CKD) patients with mild-to-moderate depression, adding mindfulness-based stress reduction (MBSR) to conventional care improved mental health, sleep quality, and quality of life more than conventional care alone. After matching, 35 patients received MBSR plus conventional management and 35 received only conventional management. The MBSR group had lower depression and better sleep scores, and higher scores for psychological resilience, mindfulness, and overall quality of life. MBSR appears to benefit psychological well-being in this population.