Journal of medical Internet research
February 20, 2024
Huijing Zou, Sek Ying Chair, Bilong Feng et al.
15 citations
A social media-based mindfulness program (MCARE) added to usual care reduced depression and anxiety more than usual care alone in 178 patients with acute coronary syndrome. At six weeks, depression dropped substantially (Cohen's d = -1.28) and anxiety dropped moderately (Cohen's d = -0.83); these benefits persisted at 12 weeks. The program also improved psychological stress, physical and emotional quality of life, dietary behavior, physical activity, and systolic blood pressure. About 76% of participants completed at least five of six sessions, and over 93% rated the program acceptable. The findings suggest that integrating a mindfulness intervention delivered partly through WeChat can help manage psychological distress and improve cardiovascular risk factors in this population.
Frontiers in pharmacology
January 1, 2022
Kelly F Paton, Dan Luo, Anne C La Flamme et al.
Kappa opioid receptor (KOR) agonists, including analogues of Salvinorin A, reduced pain in a mouse model of chemotherapy-induced neuropathic pain. 16-Ethynyl SalA was more potent than morphine at reducing mechanical allodynia, and SalA, 16-Ethynyl SalA, and EOM SalB were more potent at reducing cold allodynia. Sex differences appeared in mechanical allodynia testing: U50,488 was more potent in males, SalA more potent in females, but no sex differences occurred in cold allodynia. Chronic U50,488 (10 mg/kg) restored mechanical and cold pain responses to healthy levels over 23 days. KOR agonists may be developed to treat this condition.
ACS Chemical Neuroscience
May 8, 2020
Rachel S Crowley, Andrew P. Riley, Amy F Alder et al.
A series of analogues of kurkinorin, a non-nitrogenous μ opioid receptor (MOR) agonist derived from salvinorin A, were synthesized and tested in vitro for G-protein activation and β-arrestin-2 recruitment. Some compounds showed biased signaling, either toward β-arrestin-2 or G-protein activation. Compound 25 is a potent MOR-selective agonist with G-protein bias, over 100 times more potent than morphine and over 5 times more potent than fentanyl in vitro, and produces antinociception with limited tolerance development in vivo, despite lacking a basic nitrogen or other ionizable groups typical of opioid ligands.