Frontiers in Pharmacology
December 3, 2020
Daniela Dudysová, Karolína Janků, Michal Šmotek et al.
37 citations
Psilocybin, a serotonergic psychedelic with antidepressant potential, altered sleep architecture in healthy volunteers the night after administration. In a randomized, double-blinded trial, 20 healthy adults (10 women, ages 28–53) received psilocybin or placebo. Psilocybin prolonged REM sleep latency and showed a trend toward reduced total REM sleep duration, with no changes in NREM sleep or whole-night EEG power spectra. Contrary to expectations, psilocybin suppressed slow-wave activity in the first sleep cycle, providing no evidence for sleep-related neuroplasticity. The findings suggest that psilocybin's antidepressant properties may involve sleep changes, possibly through different mechanisms than those of classical antidepressants.
Journal of sleep research
June 1, 2021
Monika Kliková, Brian A Sharpless, Jitka Bušková
17 citations
About 23% of people with recurrent sleep paralysis report pleasant episodes, though these often include some fear. Pleasant episodes are more likely to involve illusory body movements (vestibular-motor sensations), and some individuals can intentionally induce these hallucinations. The ability to lucid dream and higher openness to new experiences are associated with pleasant episodes. Lower trauma symptoms or higher life satisfaction did not predict pleasant sleep paralysis.
Frontiers in neuroanatomy
January 1, 2024
Eva Miletínová, Monika Kliková, Amálie Dostalíková et al.
2 citations
Individuals with recurrent isolated sleep paralysis (RISP) show notable brain changes, including an increased cerebellar vermis height and a larger midbrain-pons junction. In a study of 20 participants (10 with RISP, average age 24.7; 10 controls, average age 26.3), MRI scans revealed these significant morphological differences, suggesting an over-compensatory mechanism in the brain's regulatory pathways. Despite these findings, no major variations in overall sleep structure were observed between the two groups, indicating that RISP may involve specific brain adaptations rather than broader sleep disturbances.