A unified neurocognitive theory, the theory of attention and consciousness (TAC), bridges separate accounts of consciousness and visual attention. TAC extends the global neuronal workspace model to a visual attentional workspace (VAW) controlled by executive routers, eliminating the need for explicit saliency maps. It explains phenomena including the attentional blink, working memory consolidation, illusory conjunctions, inattentional blindness, and working memory capacity. The theory proposes multiple processing stages between early visual representation and conscious access, suggests neural correlates of phenomenal consciousness, and reconciles all-or-none with graded views of conscious representation.
Vaporized 5-MeO-DMT (GH001) produces dose-dependent increases in psychedelic experience intensity in healthy volunteers, with individualized dose escalation yielding maximal effects on peak experience, mystical experience, ego dissolution, and altered states of consciousness. Higher single doses (6, 12, 18 mg) significantly increased ratings compared to 2 mg on all measures except challenging experiences. Cognition, mood, and well-being were unaffected. Vital signs remained stable, and adverse events were mild and self-resolving. Individualized dose escalation may be preferable for clinical applications aiming to maximize the psychedelic experience for therapeutic response.