Jeremy N Ruskin

2 papers in the library · 15 citations · publishing 2025

Papers

Cardiovascular effects and safety of classic psychedelics.

Nature cardiovascular research February 1, 2025 Acile Nahlawi, Leon M Ptaszek, Jeremy N Ruskin 15 citations

Psychedelics, long used in spiritual and healing contexts, are being studied as treatments for depression, PTSD, substance use disorders, and anxiety. However, data on their cardiovascular safety are limited. This review categorizes cardiovascular effects into three areas: electrophysiological effects and arrhythmia risk, structural effects and valvular heart disease risk, and vascular effects including hypertension and ischemia. It highlights crucial knowledge gaps, such as the need for studies in people with underlying cardiovascular disease, characterization of drug-drug interactions, and research on the safety of repetitive, long-term exposure, including microdosing.

DOI: 10.1038/s44161-025-00608-2 Full text

Primum Non Nocere: The Onus to Characterize the Potential Harms of Psychedelic Treatment.

The American journal of psychiatry January 1, 2025 Sharmin Ghaznavi, Jeremy N Ruskin, Stephen J Haggerty et al.

As psychedelics gain popularity as potential therapeutics, understanding their risks becomes as important as studying their benefits. This review examines known and potential harms, including enduring perceptual disturbances, triggering or worsening mania or psychosis, overuse and dependence, challenging experiences ("bad trips"), risks from increased neuroplasticity, and acute and cumulative cardiovascular effects. The authors call for continued research and monitoring, especially as these substances move into broader, less controlled use.

DOI: 10.1176/appi.ajp.20230914 Full text Adverse effects Ethics Psychedelics Risks