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Giorgia Caspani

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, East Mall, BC V6T 1Z4, Canada; Department of Microbiology and Immunology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z4, Canada; Centre for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z4, Canada; The Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2215 Wesbrook Mall, Vancouver, BC V6T 1Z4, Canada; The Vancouver Prostate Centre, Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada; Department of Medical Genetics, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC V6T 1Z4, Canada; Department of Urologic Sciences, University of British Columbia, Gordon & Leslie Diamond Health Care Centre, Level 6, 2775 Laurel Street, Vancouver, BC V5Z 1M9, Canada. Electronic address: giorgia.caspani@ubc.ca.

1 paper in the library · 13 citations · publishing 2024

Papers

Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis.

Pharmacological research September 1, 2024 Giorgia Caspani, Simon G D Ruffell, WaiFung Tsang et al. 13 citations

Psychedelics show promise for treating psychiatric disorders, but current explanations focus mainly on their action at serotonin receptors in the brain. This review argues that the gut microbiota, via the gut-brain axis, may also play a role. Evidence suggests psychedelics can alter gut microbiota composition, and microbial metabolism might influence psychedelic effects. The authors call for incorporating microbiome hypotheses into future research, which could lead to personalized psychedelic therapies tailored to individual gut microbiota profiles.