Lysergic acid diethylamide (LSD), a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders, is absorbed by the nematode Caenorhabditis elegans and acutely reduces its speed, an effect similar to that of endogenous serotonin. This response is partially mediated by the serotonergic receptors SER-1 and SER-4. The findings highlight the potential of C. elegans as a new experimental model for psychedelic research.
Lysergic acid diethylamide (LSD) extends lifespan and reduces age-related lipofuscin accumulation in the roundworm Caenorhabditis elegans, suggesting delayed aging. LSD produces effects similar to caloric restriction, such as reduced reproduction and smaller body size, without decreasing food intake. LSD also alters lipid stores and other cellular markers linked to nutrient-sensing pathways. These findings indicate that LSD engages evolutionarily conserved longevity pathways and may serve as a tool for studying serotonergic regulation of aging.