Lysergic acid diethylamide induces behavioral changes in Caenorhabditis elegans.
Neuroscience letters August 10, 2024 Isis M Ornelas, Beatriz de S Carrilho, Matheus Antonio V de C Ventura et al. 3 citations
Lysergic acid diethylamide (LSD), a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders, is absorbed by the nematode Caenorhabditis elegans and acutely reduces its speed, an effect similar to that of endogenous serotonin. This response is partially mediated by the serotonergic receptors SER-1 and SER-4. The findings highlight the potential of C. elegans as a new experimental model for psychedelic research.