[Interest and mechanisms of action of ketamine in alcohol addiction- A review of clinical and preclinical studies].
Biologie aujourd'hui January 1, 2023 Fahd Hilal, Jérôme Jeanblanc, Mickaël Naassila 3 citations
Ketamine, an atypical psychedelic used for major depression, shows promise for treating alcohol use disorder (AUD) by reducing withdrawal symptoms and alcohol craving. Preclinical and clinical studies indicate its antidepressant properties contribute to lower relapse likelihood, especially in ketamine-assisted psychotherapies. Effectiveness is linked to regulating glutamatergic pathways, enhancing neuroplasticity, and rewiring brain connectivity. However, sex differences in responses and the roles of ketamine metabolites require further investigation. Current research also examines ketamine addiction and the comorbidity of alcohol addiction and depression, which is more frequent in females.