Cell reports
July 23, 2024
Kexin Jiang, You Zheng, Liting Zeng et al.
12 citations
The trace amine-associated receptor 1 (TAAR1) plays a key role in the signaling of the hallucinogen LSD and several antipsychotic drugs. This work presents the molecular structures of the TAAR1-Gs protein complex bound to LSD and to the partial agonist RO5263397, a drug candidate for schizophrenia and addiction. Through mutagenesis, functional studies, and molecular dynamics simulations, the authors describe a versatile binding pocket in TAAR1 that adapts to recognize different ligands, including in the ligand-free state. These results clarify cross-species recognition and partial activation of TAAR1, providing a structural basis for designing new antipsychotic medications.
MycoKeys
August 30, 2022
Ya-Ya Yan, Jukka Vauras, Li-Na Zhao et al.
7 citations
A new mushroom species, Pseudosperma arenarium, is described from sandy soils under poplar and pine in northwestern China and northern Europe. It is identified by its robust form, nearly smooth cap, large spores, and unique DNA. Chemical tests show it contains muscarine, with toxin levels about five times higher in the cap (up to 4302 mg/kg) than in the stem (up to 929 mg/kg), indicating that eating different parts of the mushroom can cause varying severity of poisoning. Other toxins such as amatoxins, ibotenic acid, psilocybin, and psilocin were absent.
Toxicon : official journal of the International Society on Toxinology
August 28, 2024
Yi Yao, Yi-Zhe Zhang, Jia-Qi Liang et al.
2 citations
Two mushroom poisoning incidents in Ningxia, China, were traced to Panaeolus subbalteatus mushrooms. Symptoms appeared about half an hour after eating large amounts, including nausea, vomiting, numbness, dizziness, and disorientation. The mushrooms were identified by morphology and DNA analysis. Psilocybin and psilocin were found in the mushrooms, averaging 1532.2-1760.7 mg/kg and 114.5-136.0 mg/kg respectively. Only psilocin was detected in patients' blood and urine, at average concentrations of 0.5-1.2 ng/mL and 2.5-3.1 ng/mL. These findings can help manage future poisonings.