The effects of (2R,6R)-hydroxynorketamine on oxycodone withdrawal and reinstatement.
Drug and alcohol dependence December 1, 2023 Caryssa R Drinkuth, Michael J Lehane, Gregory C Sartor 9 citations
In oxycodone-dependent male and female mice, a single dose of the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) reduced withdrawal behaviors when given 24 hours before naloxone-precipitated withdrawal, and blocked drug-induced reinstatement of oxycodone conditioned place preference when given either 1 or 24 hours beforehand. HNK did not affect locomotion or anxiety-like behavior. The findings suggest that HNK, which lacks ketamine's misuse potential, may be effective in preclinical models of opioid use disorder without producing certain side effects.