Therapeutic Protocols Using Ketamine and Esketamine for Depressive Disorders: A Systematic Review.
Journal of psychoactive drugs January 1, 2024 Julia M K Freind, Fernando R Beserra, Bruno S Menezes et al. 9 citations
Depression is a widespread mental health disorder that causes severe emotional suffering and increases suicide risk. Ketamine and esketamine have expanded treatment options. A systematic review following PRISMA criteria analyzed existing protocols for treating depression with these substances. Results showed a predominance of medical approaches, with few studies on ketamine-assisted psychotherapy or other psychedelic-assisted therapies. Limited information was reported on psychosocial elements like preparation, psychological support during sessions, and integration of experiences. These findings suggest that treatment practices for depression with ketamine or esketamine diverge from those used with other psychedelic substances, highlighting directions for future research.