The role of ayahuasca in cell viability and oxidative stress in gastric adenocarcinoma cell line.
Natural product research July 4, 2024 Joana Gonçalves, José Francisco Cascalheira, Patrícia Valentão et al.
Ayahuasca, a psychoactive Amazonian beverage, contains N,N-dimethyltryptamine and β-carbolines that inhibit monoamine oxidase-A. Extracts from three plants used in ayahuasca preparation—Banisteriopsis caapi, Mimosa hostilis, and Peganum harmala—were tested on gastric adenocarcinoma (AGS) cells. All three extracts induced apoptosis and significantly reduced oxidative stress in these cancer cells, suggesting potential therapeutic effects against gastric cancer.