Psychoactive substances 25H-NBOMe and 25H-NBOH induce antidepressant-like behavior in male rats.
European journal of pharmacology September 15, 2023 Barbara G Ferri, Cintia O De Novais, Raquel S Bonani et al. 11 citations
Synthetic psychedelics 25H-NBOMe and 25H-NBOH, which act on serotonin 5-HT2A receptors, reduced depressive-like behavior in male adult rats. In the forced swimming test, both substances produced significantly greater motivation to escape compared to controls, suggesting antidepressant properties. All doses (0.1, 1, and 3 mg/kg) caused hallucinogenic effects as measured by head twitch responses. Locomotor activity in the open field test was unaffected except at the highest dose (3 mg/kg), which reduced movement. These findings indicate that a single dose of these compounds may have antidepressant potential, contributing to psychedelic research for psychiatric treatments.