Jianghui Xu

2 papers in the library · 80 citations · publishing 2018-2024

Papers

Breakdown in the temporal and spatial organization of spontaneous brain activity during general anesthesia

Human Brain Mapping January 28, 2018 Jianfeng Zhang, Zirui Huang, Yali Chen et al. 70 citations

During anesthetic-induced unconsciousness, two temporal features of brain activity—long-range temporal correlations (measured by power-law exponent) and temporal variability (measured by standard deviation)—both decrease globally across the brain compared to wakefulness. The spatial relationship between these two features becomes altered, or 'decoupled,' primarily due to changes in the spatial pattern of long-range temporal correlations rather than temporal variability. This suggests that the topographical organization of long-range temporal correlations is crucial for maintaining optimal neural dynamics during normal consciousness, supporting the temporo-spatial theory of consciousness.

DOI: 10.1002/hbm.23984 Unconsciousness Wakefulness Neuroscience Psychology +3

Changes in information integration and brain networks during propofol-, dexmedetomidine-, and ketamine-induced unresponsiveness.

British journal of anaesthesia March 1, 2024 Zhenhu Liang, Yu Chang, Xiaoge Liu et al. 10 citations

Information integration and brain network measures derived from EEG can distinguish conscious from unconscious states induced by three different anaesthetics. In 72 participants given propofol, dexmedetomidine, or ketamine until they lost responsiveness, permutation cross mutual information (PCMI) within frontal, parietal, and occipital regions decreased during unresponsiveness—for example, frontal within-area PCMI fell from 0.54 to 0.46. Alpha-band PCMI in the frontal region and gamma-band PCMI in posterior areas also dropped. Network analyses showed reduced clustering coefficients and nodal efficiency in frontal, parietal, and occipital areas, while normalized path length increased in delta, theta, and gamma bands, indicating impaired global integration. The three drugs produced similar changes, suggesting a common EEG signature of anaesthesia-induced unconsciousness.

DOI: 10.1016/j.bja.2023.11.033 Full text Ketamine Brain network Dexmedetomidine Electroencephalography +1