Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China; The Second Clinical School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
1 paper in the library · 6 citations · publishing 2023
Adding retigabine, a KCNQ channel opener, to a low dose of ketamine that alone had no antidepressant effect produced a strong antidepressant effect in both male and female C57BL/6J mice in the forced swim test. Retigabine also prolonged the duration of ketamine's antidepressant effect. The findings suggest that adjunctive retigabine could enhance ketamine's antidepressant properties, potentially allowing lower ketamine doses and reducing its risk of dependence.