Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.
Pharmacology, biochemistry, and behavior September 1, 2023 Yixue Qin, Haoxuan Li, Yuqi Zhang et al. 6 citations
Adding retigabine, a KCNQ channel opener, to a low dose of ketamine that alone had no antidepressant effect produced a strong antidepressant effect in both male and female C57BL/6J mice in the forced swim test. Retigabine also prolonged the duration of ketamine's antidepressant effect. The findings suggest that adjunctive retigabine could enhance ketamine's antidepressant properties, potentially allowing lower ketamine doses and reducing its risk of dependence.