Case report of a fatal 3-hydroxyphencyclidine intoxication, including blood and hair results.
Journal of analytical toxicology July 22, 2023 Alice Ameline, Morgane Baudry, Delphine Garnier et al. 1 citation
A 38-year-old man with a history of drug addiction was found dead at home with two bags of powder. Toxicological analysis of his blood detected 3-hydroxyphencyclidine (3-OH-PCP) at 524 ng/mL, the highest concentration ever reported in the literature. Other drugs found in his blood included nordiazepam, methylphenidate, amisulpride, methadone, and benzoylecgonine at levels typical of recreational abuse. Hair testing showed 3-OH-PCP at 174 pg/mg, suggesting chronic use. Analysis of the powders identified 3-OH-PCP and 5-methoxy-dimethyltryptamine with purities of 85.4% and 91.3%, respectively. 3-OH-PCP is a derivative of phencyclidine that acts on the NMDA receptor with higher affinity than phencyclidine.