Among regular cannabis users in Colorado, those who had also used psilocybin in the past three months reported higher cannabis dependence scores and more strongly endorsed using cannabis for enjoyment, boredom, and altered experience than those who had not used psilocybin recently. The correlation between cannabis dependence and the motive of altered experience was stronger for co-users. The findings suggest motivational differences and potentially greater risk of harm for people who co-use cannabis and psilocybin.
In a randomized trial, people using cannabis with cannabidiol (CBD) experienced greater decreases in symptoms of depression, anxiety, and stress over four weeks compared to those using cannabis with tetrahydrocannabinol (THC). This benefit was most pronounced among participants who reported average or high levels of perceived discrimination. No significant changes in drinking behaviors were observed. The findings suggest that CBD may help reduce negative emotional symptoms in the short term without increasing risk for alcohol misuse, and that perceived discrimination plays an important role in this relationship.