Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review.
Current neuropharmacology January 1, 2024 Lisa Burback, Suzette Brémault-phillips, Mirjam J Nijdam et al. 187 citations
Chronic PTSD is a systemic disorder with high allostatic load, shaped by advances in genetics, neurobiology, and brain imaging. Current evidence-based treatments include pharmacological and psychotherapeutic approaches, but outcomes are often suboptimal due to barriers such as comorbidity, emotional dysregulation, suicidality, dissociation, substance use, and trauma-related guilt and shame. These challenges drive emerging novel approaches: early interventions during the Golden Hours, medication augmentation, psychedelics, and brain- and nervous-system-targeted interventions. A phase-oriented treatment framework is recognized to align interventions with the disorder's pathophysiology. Revisions to guidelines and care systems will be needed as innovative treatments gain evidence.