Evolution and Comparative Analysis of Clinical Trials on Psilocybin in the Treatment of Psychopathologies: Trends in the EU and the US
Journal of Clinical Medicine September 19, 2025 Ana Flavia Burlec, Cornelia Mircea, Irina Macovei et al.
Psilocybin clinical trials are advancing more rapidly in the United States than in the European Union, driven by stronger research infrastructure, greater financial investment, and more favorable regulatory and cultural attitudes. The EU has fewer trials and slower progress, reflecting a cautious approach focused on patient safety and therapeutic efficacy. Harmonizing policies and fostering international collaboration are essential to ensure scientific rigor and patient protection as psilocybin-assisted therapies are integrated into psychiatric care.