5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats.
Scientific reports May 17, 2024 Annie C Souza, Bryan C Souza, Arthur França et al. 7 citations
The psychedelic 5-MeO-DMT alters brain activity in rats by increasing delta waves and decreasing theta waves in the hippocampus, changes that are not explained by movement. It also reduces slow and mid gamma power and disrupts theta phase modulation. The overall brain state resembles patterns seen during slow-wave sleep and REM sleep, suggesting that the drug's effects involve mixing waking behavior with sleep-like neural oscillations.