Frontiers in Molecular Neuroscience
September 4, 2018
Rafael Vitor Lima Da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz et al.
86 citations
A single injection of the psychedelic compound 5-MeO-DMT into the brain's fluid-filled spaces increased the production of new neurons in the dentate gyrus of adult mice. Treated mice had more newborn granule cells, and these cells developed more complex branch-like structures. The new neurons also showed shorter afterhyperpolarization potentials and higher action potential thresholds, indicating altered electrical properties. These effects on neurogenesis may help explain the potential antidepressant actions of DMT-like compounds.
Frontiers in Molecular Neuroscience
April 4, 2019
Rafael Vitor Lima Da Cruz, Thiago C. Moulin, Lyvia Lintzmaier Petiz et al.
4 citations
correction
This is a correction notice for a previously published article. It does not present new findings or arguments. The notice corrects errors in the original paper, specifically in the Materials and Methods section regarding the number of animals used per group and in the Results section regarding the number of animals per group for behavioral tests.
bioRxiv Preprint Server
April 26, 2025
Rafael V. Lima Da Cruz, Rêmullo B. G. De Miranda Costa, Gabriel M. De Queiroz et al.
2 citations
preprint
A single dose of the psychedelic DMT reversed depression-like behaviors and cognitive impairments in mice exposed to chronic stress, outperforming the standard antidepressant fluoxetine. When given during stress, DMT prevented anhedonia but not cognitive deficits. DMT remained effective even under anesthesia, suggesting its therapeutic action does not require the psychedelic experience. All DMT regimens increased the integration of adult-born granule cells in the brain and reduced abnormal cell integration. The findings position DMT as a promising rapid-acting antidepressant that works through structural brain repair.
Research Square
December 28, 2023
Margareth Nogueira, Daiane Ferreira Golbert, Richardson Menezes et al.
2 citations
A single high dose of the short-acting psychedelic 5-MeO-DMT alters gene expression in specific brain regions of mice, including the anterior cingulate cortex, basolateral amygdala, ventral hippocampus CA1 region, and dentate gyrus. The compound changed mRNA levels of immediate early genes Arc and Zif268 in several regions and increased TRIP8b expression in the ventral hippocampus after five days. Behaviorally, treated mice showed mixed anxiety-reducing and anxiety-increasing effects in standard tests. However, when pre-treated mice were subjected to acute stress, they had lower corticosterone levels and robust anxiety-reducing effects. These findings suggest molecular actions of 5-MeO-DMT related to its potential anxiolytic effects.
Scientific Reports
July 14, 2024
Annie C. Souza, Bryan C. Souza, Arthur França et al.
1 citation
No Summary
bioRxiv (Cold Spring Harbor Laboratory)
June 5, 2023
Annie Da Costa Souza, Bryan Da Costa Souza, Arthur S. C. França et al.
preprint
The psychedelic 5-MeO-DMT increases delta power and decreases theta power in the hippocampus of freely moving rats, effects not explained by changes in locomotion. It also dose-dependently reduces slow and mid gamma power and theta phase modulation. The overall spectral profile of awake behavior after 5-MeO-DMT resembles electrophysiological states seen during slow-wave sleep and REM sleep. These findings suggest that classical psychedelics may integrate waking behaviors with sleep-like neural activity patterns.