[Neuroimaging correlates of classical psychedelics effects: A systematic review].
L'Encephale February 1, 2025 Doriane Dost, Amine Benyamina, Laurent Karila
A systematic review of neuroimaging studies on psychedelics found that these substances reduce functional network integration, increase connectivity between brain networks, and expand the repertoire of functional connectivity patterns. Thalamic gating and emotional processing are also impaired. These changes correlate with symptom improvement in clinical populations. Despite these findings, understanding of psychedelic effects remains incomplete, and no unifying neurocognitive theory has emerged to explain the phenomena.