In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials.
Psychopharmacology June 1, 2024 Paul S Soliman, Dallece E Curley, Christy Capone et al. 22 citations
A systematic review of randomized placebo-controlled trials using psychedelics (MDMA, psilocybin, LSD, DMT/ayahuasca) with assisted therapy for psychiatric disorders found that traditional placebos are inadequate for controlling expectancy biases. Sixteen studies were reviewed. The authors suggest that active placebos and methods to limit personnel unblinding are important for future trial designs to improve internal validity and reduce response bias.