The role of frontal EEG in predicting clinical response of major depressive disorder to intranasal ketamine and esketamine.
Journal of affective disorders November 22, 2025 Carlos Trenado, Erich Seifritz, Sebastian Olbrich et al. 4 citations
Frontal EEG recordings before treatment with ketamine or esketamine in 43 people with major depressive disorder revealed that those who later responded to the medication had increased functional connectivity (measured by phase locking value and phase lag index) and decreased entropy (Renyi and Tsallis) compared to non-responders. Aperiodic spectral parameters were lower in responders but did not predict response. These EEG measures showed moderate predictive accuracy, with area under the ROC curve values of 0.7065 for Renyi entropy, 0.7101 for Tsallis entropy, and 0.7283 for phase lag index, suggesting frontal EEG patterns may serve as biomarkers for identifying individuals likely to benefit from (es)ketamine treatment.