EEG entropy modulation as a biomarker of emotion regulation and resilience.
IBRO neuroscience reports December 1, 2025 W Tanner Creel, Richard E Hartman 6 citations
Objective assessment of emotion regulation and resilience in clinical neuropsychology currently relies on self-report, which is subject to bias. This review proposes EEG entropy modulation as a candidate brain-based biomarker. Neural complexity, measured by entropy, reflects the flexible information processing underlying adaptive self-regulation. Evidence shows diminished neural complexity in emotional dysregulation and anxiety, while interventions like mindfulness may restore it. The modulation of entropy during cognitive-emotional tasks, rather than static resting-state measures, provides a more ecologically valid marker of regulatory capacity. Future research should explore task-based entropy modulation in regulatory hubs like the prefrontal cortex and integrate these data with machine learning to identify 'entropy profiles' of dysregulation and predict therapeutic response.