Effect of increasing cognitive activity participation on default mode network in older adults with subjective cognitive decline: a randomised controlled trialResearch in context
EBioMedicine March 26, 2024 Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo et al. 7 citations
Older adults with subjective cognitive decline who doubled their weekly calligraphy practice for six months showed increased functional connectivity in several default mode network regions compared with those who maintained their usual practice. The intervention group exhibited stronger connections between the medial prefrontal cortex and right lateral temporal cortex, medial prefrontal cortex and right inferior parietal lobe, left hippocampal formation and right lateral temporal cortex, and left hippocampal formation and right inferior parietal lobe. These positive neuromodulatory effects suggest that increasing engagement in cognitive activities in late life may support brain health.