Development of a physiologically based pharmacokinetic (PBPK) model of psilocybin and psilocin from magic mushroom in rats and humans
F1000Research March 15, 2021 Prinya Musikaphongsakul, Kimheang Ya, Pakpoom Subsoontorn et al. 6 citations
A physiologically based pharmacokinetic model predicts concentrations of psilocin, the active metabolite of psilocybin, in plasma and brain after intravenous and oral administration in rats and humans. The model, built from three published studies, uses seven organ compartments and shows good overall agreement with observed data, though oral doses are under-predicted and intravenous doses over-predicted. This tool may help design safer dosing regimens for therapeutic use.