Substance use initiation: The role of simultaneous polysubstance use
Drug and Alcohol Review May 21, 2012 Janine V. Olthuis, Christine Darredeau, Sean P. Barrett 79 citations
Among 226 cannabis users, most first-time use of harder illicit drugs—including cocaine, amphetamines, MDMA, heroin, and hallucinogens—involved simultaneous use of other substances, with at least 75% of participants reporting co-administration. Alcohol, tobacco, or cannabis were the substances most often used alongside the new drug. First-time use of alcohol, tobacco, and cannabis itself showed less simultaneous polysubstance use. The findings suggest that episodes involving alcohol, tobacco, or cannabis may directly facilitate the initiation of new substance use, pointing to potential risk factors for substance use progression.