Psilocin and dried extracts from Psilocybe semilanceata and Pholiotina cyanopus mushrooms collected in northeastern Poland were tested in mice for toxicity and effects on the serotonergic system. Pure psilocin was most toxic, with an LD50 of 293.07 mg/kg, while extracts from Ph. cyanopus and P. semilanceata had LD50 values of 316.87 mg/kg and 324.37 mg/kg, respectively. In behavioral head-twitch response tests, a 1 mg/kg dose of psilocin reduced head-twitches by about 46% compared to a 5-HTP control, and mushroom extracts reduced them by about 30%. Psilocin acted as a partial agonist on the serotonergic system.
The paper compares reductionist and anti-reductionist approaches to religious mysticism, arguing that each has heuristic value only within interdisciplinary dialogue. It substantiates the heuristic value of examining religious mysticism through the lens of "genuine versus inauthentic" and reveals the significance of demarcating spiritual phenomena that form a three-dimensional space of religious mysticism. Russian religious philosophy demonstrates the prerequisites of an antipsychological attitude toward mysticism in both its religious and non-religious forms, defining the specifics of the Russian psychology of religion. The limits of the anti-reductionist approach are also demonstrated. The authors conclude that the rise of neurotheology creates new perspectives for discussion and raises the question of a new composition of interdisciplinary space for studying both religious and non-religious mysticism.