Psychopharmacology
January 5, 2018
Anna Bravermanová, Michaela Viktorinová, Filip Tylš et al.
50 citations
Psilocybin, a psychedelic that activates 5-HT2A receptors, disrupted early perceptual and higher-order cognitive processing in healthy volunteers but left pre-attentive cognition intact. In a double-blind, placebo-controlled crossover trial, 20 participants (10 men, 10 women) received 0.26 mg/kg of psilocybin orally. The drug produced robust psychedelic effects and psychotic-like symptoms, decreased the amplitude of the P300 event-related potential (a marker of attentive processing) and the N100 (an early perceptual marker), but did not affect mismatch negativity (MMN), a measure of pre-attentive processing. The disruption of P300 correlated with the intensity of the psychedelic state, which depended on psilocin serum levels. These findings suggest that 5-HT2A receptors play a role in altered information processing in psychosis and schizophrenia, particularly at early perceptual and higher-order cognitive levels.
Journal of Personalized Medicine
June 19, 2022
Vojtěch Viktorin, Inga Griškova-bulanova, Aleksandras Voicikas et al.
19 citations
Psilocybin, a psychedelic compound, reduces the brain's ability to synchronize its electrical activity at 40 Hz in response to auditory clicks. In a double-blind, placebo-controlled crossover study, 20 healthy volunteers received either psilocybin (0.26 mg/kg) or placebo. Measurements taken before and after ingestion showed that psilocybin decreased the phase-locking index and amplitude of the 40 Hz auditory steady-state response, and the degree of this reduction correlated with changes in cognition and affect. These findings support the role of gamma oscillations in cognitive processing and their disruption in psychosis.
bioRxiv Preprint Server
May 5, 2026
Povilas Tarailis, Inga Griškova-bulanova
preprint
Frequency-resolved EEG microstate analysis can detect changes in brain dynamics that broadband analysis misses. In two public datasets, psilocybin microdosing produced subtle, frequency-specific effects—reduced global field power and altered delta- and theta-band microstate parameters—without broadband spatiotemporal changes. Acute inhaled DMT caused broader alterations across broadband, delta, theta, and alpha activity, indicating more extensive reorganization. In both conditions, delta-band microstate C showed increased duration and microstate D decreased occurrence, though these overlaps should be interpreted cautiously due to differences in dose, route, and context. The findings suggest frequency-resolved analysis is useful for characterizing altered resting-state brain dynamics.
Journal of neurophysiology
April 1, 2026
Inga Griškova-bulanova, Čestmír Vejmola, Tomáš Páleníček
Psilocin, the active metabolite of psilocybin, selectively disrupts auditory neural synchronization in rats in a frequency- and region-specific manner. In eight adult male Wistar rats implanted with cortical electrodes, psilocin (4 mg/kg) reduced phase-locking at 40 Hz stimulation in the right temporal cortex, with no significant changes in frontal or left temporal regions or at 80 Hz stimulation. Spectral power was globally reduced at 80 Hz after psilocin, but not consistently at 40 Hz. These results indicate that low-gamma oscillations are sensitive to serotonergic modulation via 5-HT2A receptor signaling, supporting auditory steady-state responses as translational biomarkers for altered perceptual states.