Psilocybin has no immediate or persistent analgesic effect in acute and chronic mouse pain models
bioRxiv (Cold Spring Harbor Laboratory) July 7, 2025 Akila Ram, Austen B. Casey, Robert C. Malenka et al. 2 citations preprint
Psilocybin does not produce direct analgesic effects in mice, despite suggestions from clinical and preclinical data that it might help chronic pain. Across multiple pain assays and models of acute and chronic inflammatory, neuropathic, and musculoskeletal pain, no dose of psilocybin was analgesic. The finding indicates that any therapeutic benefits for chronic pain syndromes are unlikely to come from direct pain relief.