Transgender and gender-expansive (TGE) people use psychedelics in naturalistic, non-clinical settings to explore and affirm their gender identity. Interviews with 20 TGE individuals revealed three main themes: the mindset and physical setting of a psychedelic experience shape its quality; such experiences often increase self-acceptance of gender identity through greater self-compassion and a broader concept of gender; and participants reported both challenging effects like gender dysphoria and benefits like gender euphoria. The findings suggest clinicians should help TGE clients prepare a gender-affirming setting before psychedelic use and support shifts in gender understanding afterward.
Over a five-year follow-up period, psilocybin-assisted therapy produced significant and sustained reductions in depression for people with major depressive disorder. Among the 18 participants who completed the study, 67% remained in remission for at least five years after treatment. Anxiety and functional impairment also improved. Qualitative interviews revealed lasting positive changes in mindset, emotional health, and relationships, including enhanced empathy, self-acceptance, and improved interpersonal relationships. No severe adverse events were reported. These findings support the long-term efficacy and safety of psilocybin-assisted therapy for reducing depressive symptoms and improving mental health.